Category Archives: de novo gene evolution
Our group is participating in the SMBE Satellite Meeting on de novo gene birth
Cova Vara and Chris Papadopoulos have presented their research in this week’s Symposium on de novo genes celebrated in Texas A&M University (College Station, Nov 6-9 2023). The research aims to explore the evolution of new genes in populations and … Continue reading
Filed under de novo gene evolution, mammal, micropeptide, ribosome profiling, RNA-Seq, transcriptomics, yeast
Evolutionary trajectories of new duplicated and putative de novo genes
Completely new protein sequences in genomes can arise by gene duplication or de novo. How does the mechanism of origination influence the fate of the proteins? Do duplicated proteins tend to be retained at higher rates than de novo proteins? … Continue reading
Filed under de novo gene evolution, gene duplication, micropeptide, Uncategorized, yeast
The functions of human de novo originated proteins start to be revealed
Proteins restricted to a given species or lineage are mysterious. Many of them have emerged de novo from ancestral non-coding genomic regions rather than from pre-existing genes. A new study by Vakirlis et al. shows that a large portion of … Continue reading
ERC Advanced Grant NovoGenePop
Our ERC Advanced Grant NovoGenePop has just started! This means we can already recruits scientists and start to gather data. The project will investigate how new genes arise in closely related species and populations. This will involve the development of … Continue reading
Filed under de novo gene evolution, ribosome profiling, RNA-Seq, transcriptomics, yeast
Large scale annotation of small proteins by ribosome profiling
We participate in a a new world-wide initiative for the large-scale annotation of small ORF translation events detected by ribosome profiling in the human genome. The initiative, led by researchers at Ensembl, Max Delbrück Center and Broad Institute, among others, … Continue reading
Filed under de novo gene evolution, lncRNA, micropeptide, ribosome profiling
Our research on de novo genes featured in Nature News
Research on de novo genes has been the subject of a News Feature in Nature, written by Adam Levy. The article presents the case of the arctic cod; comparison of genomic sequences from closely related fish species has shown that … Continue reading
Filed under de novo gene evolution, science, transcriptomics
Thousands of small ORFs are translated, what are they doing?
The high throughput sequencing of ribosome-protected RNA fragments, or ribosome profiling (Ribo-Seq), has uncovered the translation of thousands of novel small ORFs (< 100 amino acids) that were not annotated. These ORFs had remained hidden from annotation pipelines because of … Continue reading
Filed under de novo gene evolution, proteomics, ribosome profiling, science
New genes and functional innovation in mammals
Many human genes have counterparts in distant species such as plants or bacteria. This is because they share a common origin, they were invented a long time ago in a primitive cell. However, there are some genes that do not … Continue reading
Filed under de novo gene evolution, gene duplication, mammal, Papers
Our group portrayed at El.lipse
Nov 2016 Tweet
When we fail to detect homologues in other species, is it because they are too divergent or because they do not exist?
The increasing number of genomes available has made it possible to compare the genes and determine in which branch of the phylogenetic tree they are likely to have originated. This has led to the identification of many genes that are … Continue reading
Filed under de novo gene evolution, science, society
