Large scale annotation of small proteins by ribosome profiling

We participate in a a new world-wide initiative for the large-scale annotation of small ORF translation events detected by ribosome profiling in the human genome. The initiative, led by researchers at Ensembl, Max Delbrück Center and Broad Institute, among others, provides a first list of 7,264 new translated ORFs, including many ORFs in long non-coding RNAs, as well as upstream ORFs (uORFs) in coding transcripts.

You can read the complete post here.

Preprint: Mudge, Ruiz-Orera, Prensner et al. A community-driven roadmap to advance research on translated open reading frames detected by Ribo-seq. bioRxiv June 10, 2021.

And the paper in Nature Biotechnology!

If interested, read also this comment in Science.

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Filed under de novo gene evolution, lncRNA, micropeptide, ribosome profiling

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