Category Archives: micropeptide
Our group is participating in the SMBE Satellite Meeting on de novo gene birth
Cova Vara and Chris Papadopoulos have presented their research in this week’s Symposium on de novo genes celebrated in Texas A&M University (College Station, Nov 6-9 2023). The research aims to explore the evolution of new genes in populations and … Continue reading
Filed under de novo gene evolution, mammal, micropeptide, ribosome profiling, RNA-Seq, transcriptomics, yeast
Evolutionary trajectories of new duplicated and putative de novo genes
Completely new protein sequences in genomes can arise by gene duplication or de novo. How does the mechanism of origination influence the fate of the proteins? Do duplicated proteins tend to be retained at higher rates than de novo proteins? … Continue reading
Filed under de novo gene evolution, gene duplication, micropeptide, Uncategorized, yeast
The functions of human de novo originated proteins start to be revealed
Proteins restricted to a given species or lineage are mysterious. Many of them have emerged de novo from ancestral non-coding genomic regions rather than from pre-existing genes. A new study by Vakirlis et al. shows that a large portion of … Continue reading
Large scale annotation of small proteins by ribosome profiling
We participate in a a new world-wide initiative for the large-scale annotation of small ORF translation events detected by ribosome profiling in the human genome. The initiative, led by researchers at Ensembl, Max Delbrück Center and Broad Institute, among others, … Continue reading
Filed under de novo gene evolution, lncRNA, micropeptide, ribosome profiling
