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Large scale annotation of small proteins by ribosome profiling

We participate in a a new world-wide initiative for the large-scale annotation of small ORF translation events detected by ribosome profiling in the human genome. The initiative, led by researchers at Ensembl, Max Delbrück Center and Broad Institute, among others, … Continue reading

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Article in Ellipse by Will on his PhD journey in the lab

Will Blevins explains in an article in Ellipse his experience doing a PhD in the lab. The first challenge was culturing different yeast species, and isolating the RNA, in Lucas Carey’s lab. Then Will had to built a de novo … Continue reading

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Uncovering de novo gene birth in yeast using deep transcriptomics

We have investigated de novo gene evolution in baker’s yeast by comparing the transcriptomes of 11 different yeast species and using ribosome profiling data to identify putatively translated ORFs. The results have now been published in Nature Communications, you can … Continue reading

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The unexplored world of non-canonical peptides – a new Issue in Experimental Cell Research

A new issue in Experimental Cell Research is dedicated to different aspects of an extensive group of proteins known as micropeptides, many of which still remain hidden in genomes. These peptides are translated from open reading frames shorter than 100 … Continue reading

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Translation of neutrally evolving peptides a basis for de novo gene evolution – a short history

Our new paper “Translation of neutrally evolving peptides provides a basis for de novo gene evolution” has been published in Nature Ecology and Evolution on March 19 2018. During the course of evolution, some genes are gained and others are … Continue reading

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Science at the Youth Mobile Festival 2018

The Youth Mobile (YoMo) festival is organized by GSMA Mobile World Congress to promote STEAM areas (Science, Technology, Engineering, Art and Mathematics) among young people. The different Centers of the PRBB could be found in the stand BioJuniors. Several members … Continue reading

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How dwarf lemurs survive the dry season in Madagascar

When one thinks about hibernation images of grizzly bears waking up after a long period of inaction come to mind. However, this is a more common physiological adaptation than usually thought, and many mammals hibernate, including diverse species of rats, … Continue reading

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Pervasive translation of lncRNAS

Ribosome profiling is a sequencing tecnique that detects regions in mRNAs that are being translated. Using this technique, researchers have observed mysterious patterns of translation in many transcripts believed to be non-coding (lncRNAs, or long non-coding RNAs). The patterns are … Continue reading

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How can new genes arise de novo?

Some days ago we presented the results of our most recent work on the evolution of new genes at SMBE 2015. In the talk “The link between pervasive transcription and de novo gene evolution” we discussed the possible mechanisms of … Continue reading

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