Category Archives: lncRNA

Our group participates in ECCB 2022

We had a great time at the European Conference in Computational Biology celebrated in Sitges in September 2022. Mar gave a keynote talk on The emerging small proteome, and we presented research on cancer (mutations, neoantigens, immunotherapy, lncRNAs..) and transcriptomics … Continue reading

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Filed under lncRNA, ribosome profiling, transcriptomics, yeast

Emeline Favreau reports on her ESEB grant to spend time in our lab

Last March Emeline Favreau, a postdoctoral researcher at University College London, did a research stay at our laboratory. It was great to have her with us and learn more about wasps! Here she writes about her experience in the lab. … Continue reading

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Filed under lncRNA, RNA-Seq, transcriptomics

Large scale annotation of small proteins by ribosome profiling

We participate in a a new world-wide initiative for the large-scale annotation of small ORF translation events detected by ribosome profiling in the human genome. The initiative, led by researchers at Ensembl, Max Delbrück Center and Broad Institute, among others, … Continue reading

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Filed under de novo gene evolution, lncRNA, micropeptide, ribosome profiling

“Origins of de novo genes in human and chimpanzee” published in Plos Genetics

Novel genes are continuously emerging during evolution, but what drives this process? We have published a study in PLOS Genetics in which we find that the fortuitous appearance of certain combinations of elements in the genome can lead to the … Continue reading

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Filed under de novo gene evolution, lncRNA, Papers, science

“lncRNAs as a source of new peptides” among the most viewed posts in Haldane’s sieve 2014

Our post on the paper “Long non-coding RNAs as a source of new peptides” was among the most viewed in Haldane’s sieve during 2014. Following publication of the preprint in Arxiv and the related post in May 2014, it became … Continue reading

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Filed under de novo gene evolution, lncRNA

“Long non-coding RNAs as a source of new peptides” published in eLife

Abstract Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs are lineage-specific and do not yet … Continue reading

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Filed under de novo gene evolution, lncRNA, Papers