Tag Archives: protein evolution
Increased gain of “low complexity” regulatory domains in duplicated transcription factors
How do duplicated transcription factors, which are initially identical in sequence, specialize to perform diverse functions? We have team up with the group of Susana de la Luna, at the Center for Genomic Regulation (CRG), to try to answer this … Continue reading
Filed under amino acid repeat, gene duplication
Article in New Scientist on orphan genes
ALL ALONE Genes from nowhere: Orphans with a surprising story 16 January 2013 by Helen Pilcher NOT having any family is tough. Often unappreciated and uncomfortably different, orphans have to fight to fit in and battle against the odds to … Continue reading
Filed under Papers
New paper on the evolution of low-complexity regions in vertebrate proteins
A paper entitled “Dissecting the role of low-complexity sequences in the evolution of vertebrate proteins” by Núria Radó-Trilla and M.Mar Albà, has been accepted for publication at BMC Evolutionary Biology. Abstract Low-complexity regions (LCRs) in proteins are tracts that are … Continue reading
Filed under Papers
The paper “Structure and age jointly influence rates of protein evolution”, in collaboration with J.Plotkin lab, accepted in Plos Computational Biology.
ABSTRACT: What factors determine a protein’s rate of evolution are still under debate. Especially unclear is the relative role of intrinsic factors of present-day proteins versus historical factors such as protein age. Here we study the interplay of structural properties … Continue reading
Filed under Papers
