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Toll-Riera, Macarena, Bostick, David, Albà, M Mar, Plotkin, Joshua B

Structure and age jointly influence rates of protein evolution. (Article)

PLoS computational biology, 8 (5), pp. e1002542, 2012, ISSN: 1553-7358.

(Abstract | Links | BibTeX | Tags: Animals, Binding Sites, Computational Biology, Eukaryota, Evolution, Humans, Mice, Molecular, Protein Conformation, Protein Stability, Proteins, Proteins: chemistry, Proteins: genetics, Proteins: metabolism, Solvents)


Toll-Riera, Macarena, Laurie, Steve, Albà, M Mar

Lineage-specific variation in intensity of natural selection in mammals. (Article)

Molecular biology and evolution, 28 (1), pp. 383–98, 2011, ISSN: 1537-1719.

(Abstract | Links | BibTeX | Tags: Amino Acid Sequence, Amino Acid Substitution, Animals, Evolution, F-Box Proteins, F-Box Proteins: genetics, G-Protein-Coupled, G-Protein-Coupled: genetics, Genetic, Genetic Variation, Humans, Mammals, Mammals: genetics, Molecular, Molecular Sequence Data, N-Methyl-D-Aspartate, N-Methyl-D-Aspartate: genetics, Odorant, Odorant: genetics, Receptors, Selection, Sequence Alignment)


Mularoni, Loris, Ledda, Alice, Toll-Riera, Macarena, Albà, M Mar

Natural selection drives the accumulation of amino acid tandem repeats in human proteins. (Article)

Genome research, 20 (6), pp. 745–54, 2010, ISSN: 1549-5469.

(Abstract | Links | BibTeX | Tags: Amino Acid, Amino Acid Sequence, Amino Acids, Amino Acids: chemistry, Amino Acids: genetics, Animals, Genetic, Humans, Molecular Sequence Data, Proteins, Proteins: chemistry, Proteins: genetics, Repetitive Sequences, Selection, Sequence Homology)

Farré, Domènec, Albà, M Mar

Heterogeneous patterns of gene-expression diversification in mammalian gene duplicates. (Article)

Molecular biology and evolution, 27 (2), pp. 325–35, 2010, ISSN: 1537-1719.

(Abstract | Links | BibTeX | Tags: Animals, Evolution, Gene Duplication, Genetic, Humans, Mammals, Mammals: genetics, Models, Molecular)


Toll-Riera, Macarena, Castelo, Robert, Bellora, Nicolás, Albà, M Mar

Evolution of primate orphan proteins. (Article)

Biochemical Society transactions, 37 (Pt 4), pp. 778–82, 2009, ISSN: 1470-8752.

(Abstract | Links | BibTeX | Tags: Animals, Evolution, Gene Duplication, Genome, Genome: genetics, Molecular, Primates, Primates: genetics, Proteins, Proteins: genetics)

Rodilla, Verónica, Villanueva, Alberto, Obrador-Hevia, Antonia, Robert-Moreno, Alex, Fernández-Majada, Vanessa, Grilli, Andrea, López-Bigas, Nuria, Bellora, Nicolás, Albà, M Mar, Torres, Ferran, Duñach, Mireia, Sanjuan, Xavier, Gonzalez, Sara, Gridley, Thomas, Capella, Gabriel, Bigas, Anna, Espinosa, Lluís

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. (Article)

Proceedings of the National Academy of Sciences of the United States of America, 106 (15), pp. 6315–20, 2009, ISSN: 1091-6490.

(Abstract | Links | BibTeX | Tags: Alleles, Animals, beta Catenin, beta Catenin: metabolism, Calcium-Binding Proteins, Calcium-Binding Proteins: genetics, Calcium-Binding Proteins: metabolism, Cell Line, Cell Nucleus, Cell Nucleus: metabolism, Colorectal Neoplasms, Colorectal Neoplasms: blood supply, Colorectal Neoplasms: genetics, Colorectal Neoplasms: metabolism, Colorectal Neoplasms: pathology, Gene Expression Profiling, Gene Expression Regulation, Genetic, Genetic: genetics, Humans, Intercellular Signaling Peptides and Proteins, Intercellular Signaling Peptides and Proteins: gen, Intercellular Signaling Peptides and Proteins: met, Membrane Proteins, Membrane Proteins: genetics, Membrane Proteins: metabolism, Mice, Neoplastic, Notch, Notch: metabolism, Receptors, Signal Transduction, TCF Transcription Factors, TCF Transcription Factors: metabolism, Transcription, Transgenic, Wnt Proteins, Wnt Proteins: metabolism)


Racz, Ildiko, Nadal, Xavier, Alferink, Judith, Baños, Josep E, Rehnelt, Jennifer, Martín, Miquel, Pintado, Belén, Gutierrez-Adan, Alfonso, Sanguino, Elena, Bellora, Nicolas, Manzanares, Jorge, Zimmer, Andreas, Maldonado, Rafael

Interferon-gamma is a critical modulator of CB(2) cannabinoid receptor signaling during neuropathic pain. (Article)

The Journal of neuroscience : the official journal of the Society for Neuroscience, 28 (46), pp. 12136–45, 2008, ISSN: 1529-2401.

(Abstract | Links | BibTeX | Tags: Animals, Astrocytes, Astrocytes: immunology, Cannabinoid, CB2, CB2: genetics, CB2: immunology, CB2: metabolism, CCR2, CCR2: immunology, CCR2: metabolism, Cells, Cultured, Gene Knockout Techniques, Gene Knockout Techniques: methods, Hyperalgesia, Hyperalgesia: immunology, Hyperalgesia: physiopathology, Interferon-gamma, Interferon-gamma: genetics, Interferon-gamma: immunology, Interferon-gamma: metabolism, Knockout, Male, Mice, Microglia, Microglia: drug effects, Microglia: immunology, Microglia: metabolism, Neuralgia, Neuralgia: genetics, Neuralgia: immunology, Neuralgia: metabolism, Neurons, Neurons: immunology, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type II: immunology, Nitric Oxide Synthase Type II: metabolism, Peripheral Nerves, Peripheral Nerves: immunology, Peripheral Nerves: injuries, Peripheral Nerves: physiopathology, Peripheral Nervous System Diseases, Peripheral Nervous System Diseases: genetics, Peripheral Nervous System Diseases: immunology, Peripheral Nervous System Diseases: metabolism, Receptor, Receptors, Signal Transduction, Signal Transduction: genetics, Signal Transduction: immunology, Spinal Cord, Spinal Cord: immunology, Spinal Cord: metabolism, Spinal Cord: physiopathology, Up-Regulation, Up-Regulation: immunology)


Albà, M M, Tompa, P, Veitia, R A

Amino acid repeats and the structure and evolution of proteins. (Article)

Genome dynamics, 3 pp. 119–30, 2007, ISSN: 1660-9263.

(Abstract | Links | BibTeX | Tags: Amino Acid, Animals, Base Composition, Evolution, Humans, Molecular, Open Reading Frames, Open Reading Frames: genetics, Peptides, Peptides: chemistry, Proteins, Proteins: chemistry, Proteins: genetics, Repetitive Sequences)

Farré, Domènec, Bellora, Nicolás, Mularoni, Loris, Messeguer, Xavier, Albà, M Mar

Housekeeping genes tend to show reduced upstream sequence conservation. (Article)

Genome biology, 8 (7), pp. R140, 2007, ISSN: 1465-6914.

(Abstract | Links | BibTeX | Tags: Animals, Base Sequence, Conserved Sequence, CpG Islands, Evolution, Gene Expression, Genetic, Genetic Variation, Humans, Mice, Molecular, Molecular Sequence Data, Promoter Regions)

Mularoni, Loris, Veitia, Reiner A, Albà, M Mar

Highly constrained proteins contain an unexpectedly large number of amino acid tandem repeats. (Article)

Genomics, 89 (3), pp. 316–25, 2007, ISSN: 0888-7543.

(Abstract | Links | BibTeX | Tags: Amino Acid, Amino Acid Sequence, Animals, Complementary, Conserved Sequence, DNA, Evolution, Genetic, Humans, Mice, Molecular, Point Mutation, Proteins, Proteins: chemistry, Proteins: genetics, Repetitive Sequences, Selection, Trinucleotide Repeats)

Bellora, Nicolás, Farré, Domènec, Albà, M Mar

Positional bias of general and tissue-specific regulatory motifs in mouse gene promoters. (Article)

BMC genomics, 8 pp. 459, 2007, ISSN: 1471-2164.

(Abstract | Links | BibTeX | Tags: Animals, Databases, Gene Expression Regulation, Gene Expression Regulation: genetics, Genetic, Genetic: genetics, Mice, Nucleic Acid, Organ Specificity, Organ Specificity: genetics, Promoter Regions, Software, Transcription Factors, Transcription Factors: metabolism)

Albà, M Mar, Castresana, Jose

On homology searches by protein Blast and the characterization of the age of genes. (Article)

BMC evolutionary biology, 7 pp. 53, 2007, ISSN: 1471-2148.

(Abstract | Links | BibTeX | Tags: Amino Acid, Animals, Computational Biology, Databases, Evolution, Genes, Humans, Molecular, Phylogeny, Protein, Sequence Analysis, Sequence Homology)


Furney, Simon J, Albà, M Mar, López-Bigas, Núria

Differences in the evolutionary history of disease genes affected by dominant or recessive mutations. (Article)

BMC genomics, 7 pp. 165, 2006, ISSN: 1471-2164.

(Abstract | Links | BibTeX | Tags: Amino Acid, Animals, Caenorhabditis elegans, Caenorhabditis elegans: genetics, Computational Biology, Conserved Sequence, Dominant, Essential, Evolution, Genes, Genetic, Genetic Diseases, Genetic Structures, Humans, Inborn, Inborn: classification, Inborn: genetics, Mice, Molecular, Mutation, Pan troglodytes, Pan troglodytes: genetics, Recessive, Selection, Sequence Homology)

Blanco, Enrique, Farré, Domènec, Albà, M Mar, Messeguer, Xavier, Guigó, Roderic

ABS: a database of Annotated regulatory Binding Sites from orthologous promoters. (Article)

Nucleic acids research, 34 (Database issue), pp. D63–7, 2006, ISSN: 1362-4962.

(Abstract | Links | BibTeX | Tags: Animals, Binding Sites, Chickens, Chickens: genetics, Databases, Genetic, Genomics, Humans, Internet, Mice, Nucleic Acid, Promoter Regions, Rats, Transcription Factors, Transcription Factors: metabolism, User-Computer Interface)


Albà, M Mar, Castresana, Jose

Inverse relationship between evolutionary rate and age of mammalian genes. (Article)

Molecular biology and evolution, 22 (3), pp. 598–606, 2005, ISSN: 0737-4038.

(Abstract | Links | BibTeX | Tags: Animals, DNA, Evolution, Genome, human, Humans, Mice, Molecular, Sequence Analysis)


Albà, M Mar, Guigó, Roderic

Comparative analysis of amino acid repeats in rodents and humans. (Article)

Genome research, 14 (4), pp. 549–54, 2004, ISSN: 1088-9051.

(Abstract | Links | BibTeX | Tags: Amino Acid, Amino Acid: genetics, Amino Acid: physiology, Animals, Chromosome Mapping, Chromosome Mapping: methods, Chromosome Mapping: statistics & numerical data, Computational Biology, Computational Biology: methods, Computational Biology: statistics & numerical data, GC Rich Sequence, GC Rich Sequence: genetics, Humans, Mice, Proteins, Proteins: chemistry, Proteins: genetics, Proteins: physiology, Rats, Repetitive Sequences, Trinucleotide Repeats, Trinucleotide Repeats: genetics)

Huang, Hui, Winter, Eitan E, Wang, Huajun, Weinstock, Keith G, Xing, Heming, Goodstadt, Leo, Stenson, Peter D, Cooper, David N, Smith, Douglas, Albà, M Mar, Ponting, Chris P, Fechtel, Kim

Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes. (Article)

Genome biology, 5 (7), pp. R47, 2004, ISSN: 1465-6914.

(Abstract | Links | BibTeX | Tags: Amino Acid, Amino Acid: genetics, Animal, Animals, Chromosome Mapping, Chromosome Mapping: methods, Conserved Sequence, Conserved Sequence: genetics, Disease Models, Evolution, Fishes, Fishes: genetics, Fungal, Fungal: genetics, Genes, Genes: genetics, Genes: physiology, Genetic, Genetic Diseases, Genome, Helminth, Helminth: genetics, human, Humans, Inborn, Inborn: genetics, Inborn: physiopathology, Insect, Insect: genetics, Mice, Molecular, Mutagenesis, Mutagenesis: genetics, Nucleic Acid, Nucleotides, Nucleotides: genetics, Point Mutation, Point Mutation: genetics, Rats, Repetitive Sequences, Selection, Sequence Homology, Trinucleotide Repeat Expansion, Trinucleotide Repeat Expansion: genetics)

Gibbs, Richard A, Et al.

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. (Article)

Nature, 428 (6982), pp. 493–521, 2004, ISSN: 1476-4687.

(Abstract | Links | BibTeX | Tags: Animals, Base Composition, Centromere, Centromere: genetics, Chromosomes, CpG Islands, CpG Islands: genetics, DNA, DNA Transposable Elements, DNA Transposable Elements: genetics, Evolution, Gene Duplication, Genome, Genomics, Humans, Inbred BN, Inbred BN: genetics, Introns, Introns: genetics, Male, Mammalian, Mammalian: genetics, Mice, Mitochondrial, Mitochondrial: genetics, Models, Molecular, Mutagenesis, Nucleic Acid, Nucleic Acid: genetics, Polymorphism, Rats, Regulatory Sequences, Retroelements, Retroelements: genetics, RNA, RNA Splice Sites, RNA Splice Sites: genetics, Sequence Analysis, Single Nucleotide, Single Nucleotide: genetics, Telomere, Telomere: genetics, Untranslated, Untranslated: genetics)


Messeguer, Xavier, Escudero, Ruth, Farré, Domènec, Núñez, Oscar, Martínez, Javier, Albà, M Mar

PROMO: detection of known transcription regulatory elements using species-tailored searches. (Article)

Bioinformatics (Oxford, England), 18 (2), pp. 333–4, 2002, ISSN: 1367-4803.

(Abstract | Links | BibTeX | Tags: Animals, Binding Sites, Binding Sites: genetics, Computational Biology, DNA, DNA: genetics, DNA: metabolism, Humans, Software, Species Specificity, Transcription Factors, Transcription Factors: metabolism)